Dilute Filtration Sterilization Process for Viscoelastic Biopolymers

USPTO Patent Application US 2018/0142041 A1
Application Date: May 24th, 2018


Manufactured hyaluronic acid products are used in numerous surgical applications including viscoelastic supplementation for the treatment of osteoarthritis; however, traditional sterilization techniques result in the breakdown of such high molecular...
Application Number:
International Classification:
C08B 37/08 (20060101); C08B 37/00 (20060101); C12P 19/26 (20060101); A61K 31/728 (20060101)
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What is claimed is:

1. A process for formulating hyaluronic acid, the process comprising: (i) dissolving bulk-manufactured hyaluronic acid having a high molecular weight of 3.0±0.6 megadaltons in an aqueous medium to form a hyaluronic acid solution having a concentration of less than 0.2%;(ii) sterile-filtering the hyaluronic acid solution having a concentration of less than...



This application is a continuation of U.S. application Ser. No. 14/023,196, which was filed on Sep. 10, 2013 which, in turn, is a continuation-in-part of U.S. application Ser. No. 12/742,861, which was filed on Dec. 13, 2010 as the national phase under 35 U.S.C. 371 of PCT International Appl. PCT/IB2008/003042,...
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