BIOADHESIVE COMPOSITIONS FOR INTRANASAL ADMINISTRATION OF GRANISTRON

USPTO Patent Application US 2018/0117019 A1
Application Date: May 3rd, 2018

ABSTRACT

Sprayable aqueous pharmaceutical compositions containing granisetron or a pharmaceutically salt thereof, and pharmaceutically acceptable inactive ingredients, including tonicity agents, preservatives, and water soluble polymers with bioadhesive properties and/or capable of...
Application Number:
15/564,824
International Classification:
A61K 31/439 (20060101); A61K 9/00 (20060101); A61K 47/32 (20060101); A61K 47/38 (20060101); A61K 47/34 (20060101); A61K 47/36 (20060101); A61K 47/42 (20060101); A61P 1/08 (20060101)
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CLAIMS

What is claimed is:

1. A pharmaceutical composition, comprising (a) granisetron or a pharmaceutically salt, (b) at least one aqueous vehicle polymer that is selected from a group consisting of rheology-changeable polymer, bioadhesive polymer and the combination thereof.

DESCRIPTION

TECHNICAL FIELD

This invention relates to a pharmaceutical composition, particularly a bioadhesive composition comprising granisetron or a pharmaceutically salt thereof, as the active ingredient for intranasal administration with enhanced and prolonged granisetron absorption as well as reduced nasal stinging and dripping. The composition is suitable for rapid and sustained prevention and/or relief...
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