BIODEGRADABLE POLYMER FORMULATIONS FOR EXTENDED EFFICACY OF BOTULINUM TOXIN

USPTO Patent Application US 2018/0055779 A1
Application Date: Mar. 1st, 2018

ABSTRACT

Methods for the formulation of biodegradable microparticles for delivery of protein drugs, such as botulinum toxin, have been developed. The methods include the steps of precipitating and washing proteins with...
Application Number:
15/684,134
International Classification:
A61K 9/50 (20060101); A61K 9/51 (20060101); C01G 9/04 (20060101); C08G 63/08 (20060101)
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CLAIMS

We claim:

1. A method of formulating polymer microparticles for the controlled release of one or more encapsulated proteins, comprising the steps of: (a) dissolving protein in an aqueous solution to form a protein solution;(b) precipitating the protein from the solution to form a precipitant;(c) optionally washing the precipitant one or more times...

DESCRIPTION

CROSS-REFERENCE TO RELATED APPLICATIONS

This application claims the benefit of and priority to U.S. Ser. No. 62/380,229, filed Aug. 26, 2016, and where permissible is hereby incorporated by reference in its entirety.
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