Inhibitors Of Lactate Transporters For Use In The Treatment Of Inflammatory Diseases

USPTO Patent Application US 2017/0355987 A1
Application Date: Dec. 14th, 2017


The present invention provides methods and compositions for the treatment of inflammatory diseases such as rheumatoid arthritis using inhibitors of lactate transporters.
Application Number:
International Classification:
C12N 15/113 (20100101); A61K 39/395 (20060101); C07K 16/18 (20060101); C07K 16/28 (20060101); A61K 39/00 (20060101)
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What is claimed is:

1. A method of treating an inflammatory disease in a subject comprising administering to the subject a therapeutically effective amount of a Slc5a12 inhibitor or a Slc16a1 inhibitor.


The present invention relates to the use of specific inhibitors of lactate transporters in the treatment of chronic inflammatory diseases. The invention also relates to methods of treatment of such diseases.
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