GENETICALLY MODIFIED (R)-LACTIC ACID PRODUCING THERMOPHILIC BACTERIA

USPTO Patent Application US 2017/0275656 A1
Application Date: Sep. 28th, 2017

ABSTRACT

The invention relates to a genetically engineered thermophilic bacterial cell that is facultative anaerobic comprising: a) inactivation or deletion of the endogenous (S)-lactate dehydrogenase gene; b) introduction of a (R)-lactate...
Assignee(s):
Application Number:
15/327,495
International Classification:
C12P 7/56 (20060101); C12N 9/10 (20060101); C12N 15/52 (20060101); C07K 14/195 (20060101); C12N 15/74 (20060101); C12N 9/04 (20060101); C12N 9/88 (20060101)
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CLAIMS

What is claimed is:

1. A genetically engineered thermophilic bacterial cell that is facultative anaerobic comprising: a) inactivation or deletion of the endogenous (S)-lactate dehydrogenase gene;b) introduction of a (R)-lactate dehydrogenase gene;c) inactivation or deletion of the endogenous pyruvate formate lyase A and/or B gene.

DESCRIPTION

The present invention relates to modifying a thermophilic bacterial cell for homolactic and enantiopure (R)-lactic acid production, a genetically modified cell, and a method to produce enantiomeric pure (R)-lactic acid.
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