EXCIPIENT COMPOUNDS FOR BIOPOLYMER FORMULATIONS

USPTO Patent Application US 2017/0232103 A1
Application Date: Aug. 17th, 2017

ABSTRACT

The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or...
Application Number:
15/331,197
International Classification:
A61K 39/395 (20060101); A61K 47/12 (20060101); C07K 16/22 (20060101); A61K 47/22 (20060101); C07K 16/24 (20060101); C07K 16/32 (20060101)
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CLAIMS

What is claimed is:

1. A liquid formulation comprising a protein and an excipient compound selected from the group consisting of hindered amine compounds, aromatic compounds, functionalized amino acids, oligopeptides, short-chain organic acids, low molecular weight aliphatic polyacids, and sulfones, wherein the excipient compound is added in a viscosity-reducing amount.

DESCRIPTION

RELATED APPLICATIONS

This application is a continuation-in-part of U.S. application Ser. No. 14/966,549 filed Dec. 11, 2015 which is a continuation of U.S. application Ser. No. 14/744,847 filed Jun. 19, 2015 which claims the benefit of U.S. Provisional Application No. 62/014,784 filed Jun. 20, 2014, U.S. Provisional Application No. 62/083,623, filed Nov....
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