Novel Cell-Permeable Succinate Compounds

USPTO Patent Application US 2017/0105961 A1
Application Date: Apr. 20th, 2017

ABSTRACT

The present invention provides novel cell-permeable succinates and cell permeable precursors of succinateaimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell...
Application Number:
15/128,480
International Classification:
A61K 31/265 (20060101); C07C 327/28 (20060101); C07C 327/34 (20060101); C07C 327/32 (20060101); A61K 45/06 (20060101); C07C 327/30 (20060101)
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CLAIMS

What is claimed is:

1: A compound according to Formula (I)or a pharmaceutically acceptable salt thereof, wherein the dotted bond between A and B denotes an optional bond so as to form a ring closed structure, and whereinZ is —CH2—CH2— or >CH(CH3),A is selected from the group consisting of —SR, —OR and NHR, and...

DESCRIPTION

FIELD OF THE INVENTION

The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all...
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