Prodrugs of Succinic Acid for Increasing ATP Production

USPTO Patent Application US 2017/0105960 A1
Application Date: Apr. 20th, 2017

ABSTRACT

The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic...
Application Number:
15/128,465
International Classification:
A61K 31/225 (20060101); C07D 209/48 (20060101); A61K 31/4035 (20060101); C07C 69/40 (20060101); A61K 31/155 (20060101); A61K 45/06 (20060101)
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CLAIMS

What is claimed is:

1. A compound according to Formula (I)or a pharmaceutically acceptable salt thereof, where the dotted bond denotes an optional bond between A and B to form a cyclic structure, and whereinZ is —CH2—CH2— or >CH(CH3),A and B are independently different or the same and are selected from the group consisting...

DESCRIPTION

FIELD OF THE INVENTION

The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all...
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