Succinate Prodrugs for Use in the Treatment of Lactic Acidosis or Drug-Induced Side-Effects Due to Complex I-Related Impairment of Mitochondrial Oxidative Phosphorylation

USPTO Patent Application US 2017/0100359 A1
Application Date: Apr. 13rd, 2017

ABSTRACT

The present invention relates to a succinate prodrug for use in the treatment or prevention of lactic acidosis.
Application Number:
15/128,496
International Classification:
A61K 31/225 (20060101); A61K 31/155 (20060101); A61K 45/06 (20060101)
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CLAIMS

What is claimed is:

1. A method for treating or preventing i) lactic acidosis, ii) side-effect related to a Complex I defect, inhibition or malfunction, or iii) side-effects related to defect, inhibition or malfunction in aerobic metabolism upstream of complex I in a subject, said method comprising administering an effective amount of a succinate...

DESCRIPTION

FIELD OF THE INVENTION

The present invention relates to the use of succinate prodrugs for the treatment of mitochondria-related disorders, in particular disorders relating to Complex I of the respiratory chain. In particular the invention relates to the use of succinate prodrugs for the treatment of lactic acidosis.
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